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SCIENCE

The Literature Behind the Label.

Explore the clinical data and published literature supporting our key actives.

Clinical Evidence

The Science of Peak Performance

Every breakthrough is backed by rigorous research. Click on any statistic above to instantly load and explore the verified clinical studies behind STANMNA™.

Uthever® NMN

The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise

In a clinical trial of 60 healthy individuals, those taking NMN and PQQ showed measurable improvements in how their bodies managed energy and physical stress.

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Uthever® NMN

A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever

In a 60-day randomised clinical trial of adults aged 40+, participants taking NMN (Uthever) experienced a remarkable 38% rise in blood NAD+ levels — compared to just 14.3% in the placebo group.

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Uthever® NMN

Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

In a 6-week randomised, double-blind trial, NMN supplementation significantly raised the ventilatory threshold in amateur runners — in a clear dose-dependent response.

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PQQ

Interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study

Participants reported better body awareness, improved self-regulation, and reduced fatigue perception during exhaustive exercise. PQQ notably enhanced the brain's ability to stay focused and attentive under physical load.

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PQQ

Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation

PQQ triggers the body to build new mitochondria — the energy engines inside every cell. In laboratory studies, it increased mitochondrial activity by up to 134% and boosted cell survival under stress by 39%.

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CoQ10

Coenzyme Q10 Supplementation in Athletes: A Systematic Review

Drives ATP production, reduces oxidative stress, and significantly boosts endurance and energy efficiency in high-performance athletes during training routines.

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Alpha Lipoic Acid

Alpha-Lipoic Acid: Biological Mechanisms and Health Benefits

Called a "universal antioxidant" for good reason — ALA is the only antioxidant active in both fat and water environments, regenerating Vitamins C & E, boosting glutathione, and neutralising free radicals.

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Alpha Lipoic Acid

The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation

ALA supplementation during intense training helped athletes preserve strength and reduce muscle damage. In a chronic training week, the placebo group suffered a significant drop in performance.

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CherryCraft

CherryCraft Extract and Its Role in Accelerating Recovery and Reducing Inflammation

Helps lower exercise-induced muscle fatigue and inflammation markers, providing natural antioxidant support for athletes and active individuals.

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Magnesium

Effects of magnesium supplementation on muscle soreness in different types of physical activities

Systematic review demonstrating how magnesium supplementation optimizes muscle soreness recovery, supports healthy muscle contraction, and reduces cramp risks.

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L-carnitine

L-Carnitine Supplementation in Recovery after Exercise

Improves cellular energy efficiency, assists fat metabolism during training, and enhances overall muscle recovery post-workout.

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LIONE NMN

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias et al. (2021, Nat Rev Mol Cell Biol) reviews evidence that NAD+ levels decline with age across human and animal tissues, driven by rising NAD+-consuming enzymes (CD38, PARPs) and impaired biosynthesis, contributing to metabolic decline, inflammation, and cellular dysfunction.

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LIONE NMN

NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

Alegre & Pastore (2023, Current Nutrition Reports) reviews NAD+ precursors NMN and NR, their natural food sources, and evidence from preclinical and clinical studies supporting roles in metabolic health, neuroprotection, inflammation, and gut microbiota modulation.

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LIONE NMN

Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults

A randomized, double-blind, placebo-controlled trial (npj Aging, 2022) found that 250 mg/day oral NMN for 6–12 weeks significantly increased blood NAD+ and NAD+ metabolite levels in healthy older men, was well tolerated, and showed modest improvements in gait speed and sleep quality.

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LIONE NMN

Slc12a8 is a nicotinamide mononucleotide transporter

Grozio et al. (2019, Nature Metabolism) identified Slc12a8 as the intestinal NMN transporter and showed oral NMN restores NAD+ levels in mouse tissue. Notably, aged mice — despite lower baseline NAD+ — showed NAD+ levels rise to match young mice after NMN dosing, driven by age-upregulated Slc12a8.

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LIONE NMN

Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals

A peer-reviewed clinical study (Kimura et al., 2022) confirmed that intravenous administration of 300 mg NMN in healthy volunteers caused no adverse effects on cardiovascular, hepatic, renal, pancreatic, or haematological markers. It significantly elevated blood NAD+ levels and reduced triglycerides.

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